Xu Ming

Publisher:基础医学Release time:2017-12-26Times of browsing:154

XU, MING


Associate Professor of Clinical Pharmacy

School of Preclinical Medicine and Clinical Pharmacy

Email: mingxu@cpu.edu.cn


Our research interests focus on rational drug use and clinical drug evaluation, as well as cardiovascular pharmacology. Until now,28 SCI papers have been published, and 18 papers of them were published as the first author.17 conference papers were published in the FASEB Journal and Hypertension journal in international academic conferences. At present, our lab is supported by the fund ofNational Key New Drug Innovation Program (2017ZX09301066), the National Natural Science Foundation of China (81570413/81773732), Basic scientific research fund, high-level talent introduction in China Pharmaceutical University. Iparticipated in writing the eighth edition of the National Pharmacy Textbook "Overview of pharmacy services".  


Publications

(1) Wei W, An XR, Jin SJ, Li XX, Xu M(corresponding author).Inhibition of insulin resistance by PGE1 via autophagy-dependent Fgf21 pathway in diabetic nephropathy. Scientific Reports (Accepted)

(2) Lv ZH, Phuong TA, Jin SJ, Li XX, Xu M(corresponding author).Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes. Oncotarget. 2017; 8(53):91291-91305.

(3)Li Q, Li J, Shao H, Li XX, Yu F, Xu M(corresponding author). Inhibition of CPU0213, a Dual Endothelin Receptor Antagonist, on Apoptosis via Nox4-Dependent ROS in HK-2 Cells. Cell Physiol Biochem. 2016; 39(1):183-92.

(4)Li J, Zhang L, Jiang Z, He X, Zhang L, Xu M(corresponding author). Expression of Renal Aquaporins in Aristolochic Acid I and Aristolactam I-Induced Nephrotoxicity. Nephron. 2016; 133(3):213-21.

(5)Xu M, Hu C, Khan HH, Shi FH, Cong XD, Li Q, Dai Y, Dai DZ. Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43.Acta Pharmacol Sin. 2016; 37(2):246-54.

(6)Xu M, Zhang Q, Li PL, Nguyen T, Li X, Zhang Y. Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs.Front Biosci (Landmark Ed). 2016; 21:696-706.

(7)Xu M, Li XX, Wang L, Wang M, Zhang Y, Li PL. Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene. Cell Physiol Biochem. 2015; 37:432-44.

(8)Xu M, Li XX, Chen Y, Pitzer AL, Zhang Y, Li PL. Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes. J Cell Mol Med. 2014; 18(11):2165-75.

(9)Zhang Y, Xu M (Co-first author), Xia M, Li X, Boini KM, Wang M, Gulbins E, Ratz PH, Li PL. Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovasc Res. 2014; 102(1):68-78.

(10)Xu M, Li XX, Xiong J, Xia M, Gulbins E, Zhang Y, Li PL. Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. Biochim Biophys Acta. 2013; 1833(12):3228-36.

(11)Xu M, Li XX, Ritter JK, Abais JM, Zhang Y, Li PL. Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes. PLoS One. 2013; 8(8):e71212.

(12)Xu M, Li X, Walsh SW, Zhang Y, Abais JM, Boini KM, Li PL. Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes. Am J Physiol Cell Physiol. 2013; 304(5):C458-66.

(13)Xu M, Xia M, Li XX, Han WQ, Boini KM, Zhang F, Zhang Y, Ritter JK, Li PL. Requirement of translocated lysosomal V1 H(+)-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells. Mol Biol Cell. 2012; 23(8):1546-57.

(14)Xu M, Zhang Y, Xia M, Li XX, Ritter JK, Zhang F, Li PL.NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice. Free Radic Biol Med. 2012; 52(2):357-65.

(15)Xu M, Tang YQ, Dai DZ, Zheng YF, Cheng YS, Zhang Q, Dai Y. Comparison of sildenafil with strontium fructose diphosphate in improving erectile dysfunction against upregulated cavernosal NADPH oxidase, protein kinase Cå, and endothelin system in diabetic rats. J Pharm Pharmacol. 2012; 64(2):244-51.

(16)Xu M, Dai DZ, Zhang Q, Cheng YS, Dai Y. Upregulated NADPH oxidase contributes to diabetic testicular complication and is relieved by strontium fructose 1,6-diphosphate. Exp Clin Endocrinol Diabetes. 2010; 118(7):459-65.

(17)Xu M, Ji H, Dai DZ, Tang XY, Dai Y. Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats. J Pharm Pharmacol. 2008; 60(6):739-45.

(18)Xu M, Dai DZ, Dai Y. Normalizing NADPH Oxidase Contributes to Attenuating Diabetic Nephropathy by a Dual Endothelin Receptor Antagonist CPU0213 in Rats. Am J Nephrol. 2008; 29(3):252-6.