Wu Zhaoqiu

Publisher:基础医学Release time:2017-12-26Times of browsing:192

Curriculum Vitae


 Zhao-Qiu Wu, Ph.D.

 Professor and Principal Investigator

 Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy

 State Key Laboratory of Natural Medicines

 Jiangsu Provincial Key Laboratory of Carcinogenesis and Intervention

 China Pharmaceutical University

 639 Longmian Ave., Nanjing 211193, China

 Phone: +86-13809003346

 Email: zqwu@cpu.edu.cn


EDUCATION:

09/1995 – 07/2000   Nanchang University, Bachelor Degree of Medicine

09/2000 – 07/2003   China Pharmaceutical University, Master Degree of Pharmacology

09/2003 – 07/2006   Chinese Academy of Sciences University, Ph.D. Degree of Pharmacology  


POSTDOCTORAL TRANINING:

 08/2006 – 08/2008 /  Research Fellow, Center for Cancer Research, Purdue University, West Lafayette, IN, USA

 09/2008 – 10/2009   Research Fellow, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA


ACADEMIC APPOINTMENTS:

 11/2009 – 11/2014   Research Assistant Professor, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA

 12/2014 – present /  /Professor, Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

 12/2015 – present / /  Professor, National Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China


RESEARCH INTERESTS:

 Tumor initiation and progression, cancer stem cells, transgenic mouse tumor models, targeted drug screening and R & D


GRANT SUPPORT:

  1.  I.D. No.: NSFC 81572745 (NSFC, National Natural Science Foundation of China)

 Role: Principal Investigator

Title: Functional study of Snail1 in breast tumor initiation and progression Period: 01/2016 – 12/2019

Direct cost: 620,000 Yuan (RMB)

  1. I.D. No.: NSFC 91539115 (NSFC, National Natural Science Foundation of China)

Role: Principal Investigator

Title: Role of Snail1/ MT1 signaling axis in neovascularization in atherosclerotic plaque

Period: 01/2016 – 12/2018

Direct cost: 800,000 Yuan (RMB)

  1. I.D. No.: BK20170029 (Jiangsu Provincial Natural Science Fund for Distinguished Young Scholar)

Role: Principal Investigator

Title: A Zeb1/p53 axis in stromal fibroblasts suppresses mammary epithelial tumors

Period: 06/2017 – 06/2020

Direct cost: 1,000,000 Yuan (RMB)

  1. I.D. No.: “Shuang-Chuang” Team Innovation Project (JiangSu provincial government)

Role: Principal Investigator

Title: Screening, research and development of novel peptides for cancer therapy

Period: 01/2016 – 12/2018

Direct cost: 1,000,000 Yuan (RMB)

  1. I.D. No.: “Shuang-Chuang” Individual Innovation Project (JiangSu provincial government)

Role: Principal Investigator

Title: Screening, research and development of novel immunotherapeutic drugs for cancer

Period: 01/2017 – 12/2019

Direct cost: 500,000 Yuan (RMB)

  1. I.D. No.: Endowment of Jiangsu Specially-Appointed Professor (JiangSu provincial government)

Role: Principal Investigator

Title: Molecular mechanisms for pathological angiogenesis in diseases

Period: 01/2015 – 12/2017

Direct cost: 500,000 Yuan (RMB)

  1. I.D. No.: The Start-up Fund from China Pharmaceutical University

Role: Principal Investigator

Title: Molecular mechanisms by which zinc finger transcriptional factors control malignant tumor initiation and progression and its targeted therapy

Period: 01/2015 – 12/2020

Direct cost: 4,600,000 Yuan (RMB)


SCIENTIFIC ACTIVITIES:

Editorial board

Am. J. Physiol.-Gastrointest. Liver Physiol. (2010 – 2015)

Associate editor

Pathol. Res. Pract. (2017 – present)


SELECTED PUBLICATIONS (*corresponding author)

  1. Ting Ni, Xiao-Yan Li, Na Lu, Teng An, Zhi-Ping Liu, Rong Fu, Wen-Cong Lv, Yi-Wei Zhang, Xiao-Jun Xu, R. Grant Rowe, Yong-Shun Lin, Amanda Scherer, Tamar Feinberg, Xiao-Qi Zheng, X. Shirley Liu, Qing-Long Guo, Zhao-Qiu Wu*, Stephen J. Weiss*. Snail1-Dependent p53 Repression Regulates Expansion and Activity of Tumor-Initiating Cells in Breast Cancer. Nat. Cell Biol., 2016, 18 (11): 1221-1232. IF: 20.1.

  2. Rong Fu, Yan Chen, Xiaoping Wang, Qinglong Guo*, Zhao-Qiu Wu*. Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis. Oncotarget, 2016, 7: 5715-5727. IF: 5.1.

  3. Zhao-Qiu Wu, Grant R Rowe, Kim-Chew Lim, Yongshun Lin, Yi Tang, Tamar Y Feinberg, Xiaoyan Li, Farideh Sabeh, Ivan Maillard, Stephen J Weiss*. A Snail1-Dll4/Notch Axis Controls Embryonic Vascular Development. Nat. Commun., 2014, 4 (5): 3998-4013. IF: 12.5.

  4. Zhao-Qiu Wu, Thomas Brabletz, Eric Fearon, Amanda L Willis, Casey Yuexian Hu, Xiaoyan Li, Stephen J Weiss*. The Canonical Wnt Suppressor, Axin2, Promotes Colon Carcinoma Oncogenic Activity. Proc. Natl. Acad. Sci., USA., 2012, 109 (28): 11312-11317. IF: 9.5.

  5. Zhao-Qiu Wu, Xiaoyan Li, Casey Y Hu, Michael Ford, Celina G Kleer, Stephen J Weiss*. Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proc. Natl. Acad. Sci., USA., 2012, 109 (41): 16654-16659. IF: 9.5.

  6. Zhao-Qiu Wu, Xiaoqi Liu*. Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing. Proc. Natl. Acad. Sci., U.S.A.,2008, 105 (6): 1919-1924. IF: 9.5.

  7. Zhao-Qiu Wu, Xiaoming Yang, Greg Weber, Xiaoqi Liu*. Plk1 phosphorylation of TRF1 is essential for its binding to telomeric DNA. J. Biol. Chem., 2008, 283 (37): 25503-25513. IF: 5.8.