Hu Rong

Publisher:基础医学Release time:2017-12-26Times of browsing:219

Rong HuPh.D. Professor


 Department of Physiology

 School of Basic Medical Sciences and Clinical Pharmacy

 China Pharmaceutical University

 24 Tongjiaxiang

 Nanjing, 210009

 86(25) 83271029

 ronghu@cpu.edu.edu



EDUCATION


Rutgers, the State University of New Jersey, Piscataway, NJ

Department of Pharmaceutics, Ernest Mario School of Pharmacy

Ph. D. conferred June, 2005

Major: Pharmaceutical Sciences


RESEARCH INTEREST


(1) Studies on phytochemicals-mediated cellular signaling and chemoprevention against inflammation-associated carcinogenesis. (2) Nrf2- and Nlrp3-mediated signaling in regulating oxidative stress and inflammation.



SELECTED PUBLICATIONS

  1. Liu XZhang XDing YZhou WTao LLu PWang YHu R*. Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming. Antioxid Redox Signal. 2016 Aug 9. [Epub ahead of print]

  2. Liu XZhou WZhang XLu PDu QTao LDing YWang YHu R*. Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation. BiochemPharmacol. 2016 Jul 15;112:37-49. doi: 10.1016/j.bcp.2016.05.002. Epub 2016 May 13.

  3. Du QWang YLiu CWang HFan HLi YWang JZhang XLu JJi H*, Hu R*. Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-β-catenin axis. Oncotarget. 2016 Feb 21. doi: 10.18632/oncotarget.7554.

  4.  Du Q, Wang Q, Fan H, Wang J, Liu X, Wang H, Wang Y*, Hu R*. Dietary cholesterol promotes AOM-induced colorectal cancer through activating the NLRP3 inflammasome. Biochem Pharmacol. 2016 Feb 24. pii: S0006-2952(16)00116-7. doi: 10.1016/j.bcp.2016.02.017.

  5.  Wang Y, Wang H, Qian C, Tang J, Zhou W, Liu X, You Q*, Hu R*. 3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome. Biochem Pharmacol. 2016 Feb 1;101:71-86.