Fu Jihua

Publisher:基础医学Release time:2017-12-26Times of browsing:202


Name:

Fu Jihua

Education:

Ph.D.


Positions:

Master Tutor of China Pharmaceutical University

Academic title:

Associated Professor

Phone:

+86-13951933013

Tel:

025-86185226

E-mail:

fjhfy_cpu@163.com

Postal Code:

210009

Mailing Address:

#24 Tong Jia Xiang, Nanjing, China, Department of Physiology, China Pharmaceutical University


Education

1979-1983 Peking University, Beijing, China, B.S. in physiology
2001-2004 China Pharmaceutical University, Nanjing, China, M.A. in Pharmacology
2005-2010 China Pharmaceutical University, Nanjing, China, Ph.D. in Pharmacology


Research Directions

Professor Fu’s laboratory is mainly focused on:(1) Common feature of metabolic diseases including type 2 diabetesmellitus, non-alcoholic fatty liver disease, atherosclerosis, and diabetic nephropathy; (2) exploring the relationship between peripheral 5-HT system and metabolic diseases.


Achievements

Professor Fu has a unique understanding on metabolic diseases. Fu’s team has found that high-fat diet and stress stimulation have a significant synergistic effect on the occurrence of metabolic syndrome, not only can promote the conversion of fatty liver to steatohepatitis, but also promote insulin resistance, dyslipidemia, and blood vessels, heart disease. They have a major discovery of the pathogenesis of insulin resistance-related diseases. It was first found worldwide that 5-HT can be synthesized in the liver, and that abnormality of peripheral 5-HT system is the common and decisive reason of insulin resistance-related diseases. They have confirmed that there is a common essential reason for high-fat diet and glucocorticoid-induced insulin resistance to be an increase in peripheral and hepatocyte 5-HT synthesis and 5-HT2R upregulation. More than 50 research papers have been published, many of which are collected by SCI. Six invention patents are applied as first inventor. Studies regarding pre-clinical pharmacodynamics and toxicology of the multiple new drugs have been completed through cooperation with the companies.


Funding & Research Projects

(1) 2014-2016 Nanjing Military Region Medical and Health Research Fund, "Xiang Qing painkillers on military training injury rapid analgesic anti-inflammatory effect of clinical and mechanism"Project number: ZX26.
(2) 2016-2019
National Natural Science Foundation of China, "Study on effects of peripheral 5-HT system in glucocorticoid orhigh-lipid diet-induced insulin resistance "Project number: 81570720.


Publications (Typical)

[1] Jihua Fu*, Shaoxin Ma, Xin Li, Shanshan An, Tao Li, Keke Guo, Min Lin, Wei Qu1, Shanshan Wang, Xinyue Dong, Xiaoyu Han, Ting Fu, Xinping Huang, Tianying Wang, Siyu He. Long-term Stress with Hyperglucocorticoidemiainduced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver. International Journal of Biological Sciences. 2016; 12(2): 219-234.
[2] Tao Li, Keke Guo, Wei Qu,YingHan, Shanshan Wang, Min Lin, Shanshan An, XinLi, Shaoxin Ma, Tianying Wang, Shiya Ji, Christian Hanson, JihuaFu*. Important role of 5-hydroxytryptamine in glucocorticoid-induced insulin resistance in liver and intra-abdominal adipose tissue of rats. J Diabetes Investig. 2016; 7: 32–41.
[3] Shaoxin Ma, Tao Li, Keke Guo, Xin Li, Shanshan An, Shanshan Hou, RuChen, BoYang, Siyu Liu, Jihua Fu*. Effective treatment with combination of peripheral 5-hydroxytryptamine synthetic inhibitor and 5-hydroxytryptamine 2 receptor antagonist on glucocorticoid-induced wholebody insulin resistance with hyperglycemia. J Diabetes Investig. 2016, doi: 10.1111/jdi.12526.
[4] Xin Li, Keke Guo, Tao Li, Shaoxin Ma, Shanshan An, Shanshan Wang, Jiao Di, Siyu He, Jihua Fu*. 5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats. Obesity Research & Clinical Practice. 2016, http://dx.doi.org/10.1016/j.orcp.2016.03.015.
[5] Shudong Wang, Tao Li, Wei Qu, Xin Li, Shaoxin Ma, Zheng Wang, Wenya Liu, Shanshan Hou, and Jihua Fu*. The Effects of Xiangqing Anodyne Spray on Treating Acute Soft-Tissue Injury Mainly Depend on Suppressing Activations of AKT and p38 Pathways. Evidence-Based Complementary and Alternative Medicine. 2016, http://dx.doi.org/10.1155/2016/9213489.
[6] Ying Han, Min Lin, Xiaobin Wang, Keke Guo, Shanshan Wang, Mengfei Sun, Jiao Wang, Xiaoyu Han, Ting Fu, Yang Hu, Jihua Fu*. Basis of aggravated hepatic lipid metabolism by chronic stress in high-fat diet-fed rat. Endocrine. 2015, 48:483–492.
Siyuan Gao, Xue Han, Jihua Fu*, Xiaoling Yuan, Xing Sun, Qiang Li. Influence of chronic stress on the compositions of hepatic cholesterol and triglyceride in male Wistar rats fed a high fat diet. Hepatology Research, 2012; 42: 686–695
[7] WEI Wei, XIE Sheng-rong, FU Ji-hua*, LIU Wen, QI Jian-ping, PING Qi-neng*. Anti-inflammatory Effects of Components in Shuxiong Tablet and Its Possible Formulary Rationality. Chinese Herbal Medicines, 2010, 2(4): 297-304.